KISSPEPTIN-10 10ml (5mg/1ml) + 2ml Solvent

Description

What is Kisspeptin?

Kisspeptin (a.k.a. metastin) is a naturally occurring protein in humans that plays an important role in hormone signalling during puberty and reproduction. It is also thought to alter mood and behaviour, promote angiogenesis, and regulate kidney function. The peptide has also been found in the brain and suppresses tumour growth and metastasis (spread). The peptide is of greatest scientific interest for its ability to influence gonadotropin-releasing hormone (GnRH).

References

Javanmard and Golzar (2015) The Effects of kisspeptin-10 on Migration and Proliferation of Endothelial Cell. Adv. Biomed. Res. 4(1) 41 PMID: 25789267
De Bond and Smith (2014) Kisspeptin and energy balance in reproduction. Reproduction 147(3) R53 PMID: 24327738
Uenoyama et al (2016) The roles of kisspeptin revisited: inside and outside the hypothalamus. J. Reprod. Dev. 62(6) 537 PMID: 27478063

The biologically active C-terminal region of human Kisspeptin. Kisspeptin is cleaved from a 145 amino acid precursor to a 54 amino acid peptide in humans and a 52 amino acid peptide in mice. Smaller isoforms of 14, 13 and 10 amino acids have also been isolated, each sharing the common C-terminal sequence. Kisspeptin-10 (KP-10) is the most potent member of the kisspeptin family and the plasma half-life is approximately 6 fold shorter than KP-54. KP-10 is produced by the trophoblast cells in the first trimester of pregnancy and inhibits cell migration primary trophoblasts which are essential for placental invasion.

Kisspeptin, a product of the KISS1 gene, is a hypothalamic neuropeptide that stimulates gonadotropin-releasing hormone (GNRH) neurons and drives fertility. Kisspeptin binds specifically to the G-protein-coupled receptor-54, now known as Kiss1r, which is expressed in almost all GnRH neurons. Kiss1r is also expressed in other areas of the brain and periphery, highlighting other possible roles for kisspeptin outside of reproduction

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